Three Nigeria internationals, Wilfred Ndidi and Kelechi Iheanacho of Leicester City and Oladeji Olayinka of Sylivia Prague were on Europa league duty for their respective teams on Thursday evening.
While Ndidi and Olayinka played the entire 90 minutes duration of the match, Kelechi Iheanacho was brought in to replace Vardy in the 64th minute.
Brendan Rodgers’ side, who currently sit third in the Premier League, failed to create many clear-cut chances on a frustrating evening in Prague.
Harvey Barnes came closest, when he was denied from close range in the first half, but the hosts put Leicester under some pressure after the break.
The return leg will be played at King Power Stadium on Thursday, 25 February.