Premier League title record holders, Manchester United, have lost 2-1 to Danish side FC Midtjylland in the first leg of their Europa League last-32 tie.
United were without a number of injured players, including Wayne Rooney, and lost David de Gea in the warm-up.
They took the lead through Memphis Depay’s shot but Sergio Romero, who stepped in for De Gea, was unable to prevent Pione Sisto equalising.
United’s Jesse Lingard hit the bar before Paul Onuachu struck the winner.
After losing to Sunderland 2-1 on Saturday, the Red Devils are six points shy of the top four in the Premier League, leaving qualification for next season’s Champions League very much in the balance.