Speaking from the White House, Mr Biden described the prince as “a heck of a guy”.
“His lifetime of service to the United Kingdom and the whole commonwealth was visible to everybody for a long, long time,” he said.
“I think he’s going to be missed, particularly in the United Kingdom. Ninety-nine years old, he never slowed down at all. Which I admire the devil out of.”
Mr Biden is reportedly due to meet the Queen at Buckingham Palace in June.
On Friday, White House press secretary Jen Psaki said it was not yet determined whether the president would attend the duke’s funeral.
He and his wife, First Lady Jill Biden, also released a joint statement praising Prince Philip’s “decades of devoted public service”.
His legacy “is evident in the worthy causes he lifted up as patron, in environmental efforts he championed, in the members of the Armed Forces that he supported, in the young people he inspired, and so much more,” the pair wrote.