After a 100-day absence because of the coronavirus pandemic, Aston Villa v Sheffield United will kick off the English top-flight’s resumption.
It is the first of 92 league games that will be packed into a frantic 40 days before the season concludes on 26 July.
Fixtures will be played behind closed doors as one of a host of measures to prevent any further cases of the virus.
A minute’s silence to remember those who have died with coronavirus will be held before the first matches, while heart-shaped badges in tribute to frontline NHS staff will also be worn on kits.
For the first 12 matches of the restarted campaign, all player names on the back of shirts will be replaced by “Black Lives Matter”.
This follows the death of George Floyd in the United States, which has sparked protests worldwide.
Over eight rounds of twice-weekly coronavirus screenings of Premier League players and staff, there have been 16 positive results from 8,687 tests.
All remaining 92 games will be broadcast live, with four matches to be shown on the BBC – the first to be made free-to-air on terrestrial television since the Premier League’s inception in 1992.